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Search for "solvent-free reactions" in Full Text gives 11 result(s) in Beilstein Journal of Organic Chemistry.
New one-pot synthesis of 4-arylpyrazolo[3,4-b]pyridin-6-ones based on 5-aminopyrazoles and azlactones
Beilstein J. Org. Chem. 2023, 19, 1155–1160, doi:10.3762/bjoc.19.83
- ]pyridones 3 obtained by this method vary widely [31][32][33]. Solvent-free reactions are convenient from both economic and environmental points of view. We obtained tetrahydro-1H-pyrazolo[3,4-b]pyridinone 3a by heating 5-aminopyrazole 1 with azlactone 2a in the absence of solvent at 150 °C in 62% yield
Clauson–Kaas pyrrole synthesis using diverse catalysts: a transition from conventional to greener approach
Beilstein J. Org. Chem. 2023, 19, 928–955, doi:10.3762/bjoc.19.71
- . Furthermore, many solvent-free reactions and solid-supported reagents are becoming increasingly popular in organic synthesis. Moreover, in order to increase the product yield, different green catalysts were used in the synthesis of numerous organic and bioorganic molecules while reducing the amount of excess
- procedure is explained in the first section, and the green protocol is covered in the second (Figure 2). The second section is further divided into three subsections that covers the various eco-friendly green processes used, such as, (i) reactions in water, (ii) solvent-free reactions, (iii) microwave
Polymer and small molecule mechanochemistry: closer than ever
Beilstein J. Org. Chem. 2022, 18, 1225–1235, doi:10.3762/bjoc.18.128
- -free ball milling has enabled to surpass the insolubility and recalcitrant reactivity of cellulose [36][37], chitin [38][39], and lignin (Figure 2) [40][41]. In addition to allowing solvent-free reactions, mechanical forces generated inside ball mills can depolymerize biomass through cleavage pathways
Efficient method for propargylation of aldehydes promoted by allenylboron compounds under microwave irradiation
Beilstein J. Org. Chem. 2020, 16, 168–174, doi:10.3762/bjoc.16.19
- time and the possibility to perform solvent-free reactions [30]. However, the relative “greenness” of microwave-assisted reactions is still a point of discussion. For example, the question about the energy efficiency of microwave vs conventionally heated reactions must, in general, be evaluated with
An overview on recent advances in the synthesis of sulfonated organic materials, sulfonated silica materials, and sulfonated carbon materials and their catalytic applications in chemical processes
Beilstein J. Org. Chem. 2018, 14, 2745–2770, doi:10.3762/bjoc.14.253
- . carried out the synthesis of 2H-indazolo[2,1-b]phthalazinetrione derivatives 55 and triazolo[1,2-a]indazoletrione derivatives 81 using solvent-free reactions between aldehydes 7, dimedone (20), and phthalazine (54) or N-phenylurazoles (80) at 80 °C in the presence of catalytic amount of a mesoporous SBA
β-Hydroxy sulfides and their syntheses
Beilstein J. Org. Chem. 2018, 14, 1668–1692, doi:10.3762/bjoc.14.143
- their corresponding analogs (Brønsted acid p-TsOH and Lewis base n-Bu3P, respectively) as shown in Scheme 2 [21]. In comparison to the reaction carried out under the same reaction conditions but in aqueous or organic media, it was found that the solvent-free reactions provided the β-hydroxy sulfides in
Bromide-assisted chemoselective Heck reaction of 3-bromoindazoles under high-speed ball-milling conditions: synthesis of axitinib
Beilstein J. Org. Chem. 2018, 14, 786–795, doi:10.3762/bjoc.14.66
- [33][34] and axitinib [35][36][37][38] (Scheme 1). Mechanochemistry as a burgeoning technique to promote solvent-free reactions has led to remarkable advances [39][40][41][42], particularly for cross-coupling reactions [43][44][45], involving Heck coupling with the aid of stoichiometric amounts of
Solvent-free sonochemistry: Sonochemical organic synthesis in the absence of a liquid medium
Beilstein J. Org. Chem. 2017, 13, 1850–1856, doi:10.3762/bjoc.13.179
- studying a larger scope of chemical reactions and the mechanism behind which the liquid/solvent-free reactions occur. It also provides a means of applying a gentler form of mechanical energy to a system which may increase the range of organic and inorganic mechanochemical transformations that can be
Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method
Beilstein J. Org. Chem. 2012, 8, 534–538, doi:10.3762/bjoc.8.61
- absence of solvents and catalysts have been accomplished for greener and cleaner syntheses [1][2][3][4][5][6]. As the typical representative of solvent-free reactions, the grinding technique has been widely used in organic synthesis [7][8][9][10][11][12][13]. Compared to traditional methods, some organic
Dioxane dibromide mediated bromination of substituted coumarins under solvent-free conditions
Beilstein J. Org. Chem. 2012, 8, 323–329, doi:10.3762/bjoc.8.35
- electron-withdrawing group. Efficacy of the solvent-free bromination protocol with DD. Solvent-free reactions of substituted coumarins with dioxane dibromide. Supporting Information Supporting Information File 58: General experimental procedure for the preparation of DD and solvent-free bromination of
SbCl3-catalyzed one-pot synthesis of 4,4′-diaminotriarylmethanes under solvent-free conditions: Synthesis, characterization, and DFT studies
Beilstein J. Org. Chem. 2011, 7, 135–144, doi:10.3762/bjoc.7.19
- performing theoretical calculations at the HF and DFT levels of theory by standard 6-31G*, 6-31G*/B3LYP, and B3LYP/cc-pVDZ methods and good agreement was obtained between experimental and theoretical results. Keywords: diaminotriarylmethane; SbCl3; solvent-free reactions; synthesis; vibrational analysis
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